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Using population genetics and phylogeny to assist functional analysis

Organizers:

Frederic Berger and Alexander Dammermann

Background:

Research on chromatin and chromosome biology to a large extent depends on understanding the function of the proteins involved. Proteins associated with chromatin and chromosomes tend to be highly conserved and have been under selective constraint during evolution. Hence considering phylogeny and population genetics can provide important functional insights. Both genome-wide association studies (GWAS) and phylogenetic approaches require specialized expertise. The aim of this workshop is to equip students with the necessary theoretical and practical knowledge to undertake such analyses.

Objectives:
  • To introduce basic concepts of phylogenetic analysis and GWAS
  • To illustrate how these approaches can be applied to functional analysis of proteins
  • To guide students through practical essential steps using sequence databases and GWAS resources.

 

Contents:
  • Introduction to resources to study phylogeny
  • Theory of phylogenetic tree reconstruction, phylogenetic profiling and ancestral protein reconstruction.
  • Introduction to GWAS resources
  • Major principles of GWAS analyses
  • Rotating ateliers for practical studies, with tutorial groups of 4 students.

 

MFPL

 

 

UniVie

 

 

GMI

 

 

IMBA Logo

 

 

FWF